The match at Jonsson Kings Park kicks off at 13h00 and will be broadcast live on SuperSport.
After rupturing a patella tendon against the Vodacom Bulls, Sikhumbuzo Notshe has unfortunately been ruled out of action for a few months, which has necessitated a re-jig of the loose-trio.
Henco Venter moves to No 8 with Thembelani Bholi taking his place on the side of the scrum.
At lock, JJ van der Mescht will start in place of the hard-working Ruben van Heerden, who moves to the bench.
In the final change, Marius Louw returns to the side and takes over from Jeremy Ward at centre.
Springbok wing Sbu Nkosi is also back in the starting team after he pulled out shortly before the clash against the Vodacom Bulls in Pretoria, with Werner Kok moving back to the bench.
“The guys are proud, they have a lot of fight in them,” said Everitt.
“Despite last week’s loss, there is still a lot of rugby to be played, we have three games and it starts with our come-back this Saturday and we’re certainly not out of the race.
"We’re still in a really good position, the Bulls are only three points ahead of us, we still have them at home and we haven’t lost at Jonsson Kings Park for a long period of time. We want to bounce back and we do want to win this competition.”
Cell C Sharks: 15 Aphelele Fassi, 14 Sbu Nkosi, 13 Lukhanyo Am (captain), 12 Marius Louw, 11 Yaw Penxe, 10 Curwin Bosch, 9 Jaden Hendrikse, 8 Henco Venter, 7 Thembelani Bholi, 6 Siya Kolisi, 5 Reniel Hugo, 4 JJ van der Mescht, 3 Thomas du Toit, 2 Fez Mbatha, 1 Ox Nche. Replacements: 16 Kerron van Vuuren, 17 Ntuthuko Mchunu, 18 Wiehahn Herbst, 19 Ruben van Heerden, 20 Phepsi Buthelezi, 21 Sanele Nohamba, 22 Manie Libbok, 23 Werner Kok.
Date: Saturday 22 May
Venue: Jonsson Kings Park, Durban
Referee: Marius van der Westhuizen
Assistant Referees: Cwengile Jadezweni, Ashleigh Murray-Pretorius
Television Match Official: Stuart Berry
TV: SuperSport Rugby and Grandstand channels