The four experienced players will all start at Jonsson Kings Park, where the action starts at 13h00 - with SuperSport broadcasting it live.
Orie missed out last week due to concussion protocols, while Schickerling has recovered from an ankle injury to take his place in the second row behind the unchanged all-Springbok front row of captain Steven Kitshoff, Bongi Mbonambi and Frans Malherbe.
Du Toit is back after being rested last week and forms a loose trio with Willie Engelbrecht and Evan Roos.
Nel has returned after spending the last two weeks with the Springbok Sevens team and is in midfield in the only backline change.
DHL Stormers head coach John Dobson said that there has been an emphasis on executing the gameplan as accurately as possible this week.
“We want to make the best use of the opportunities that we create, which means that we must be focused and as accurate as possible in everything that we do," said Dobson.
“All of the players coming in this week have played a role in this campaign already and we are looking forward to a cohesive team performance.”
DHL Stormers: 15 Damian Willemse, 14 Sergeal Petersen, 13 Ruhan Nel, 12 Rikus Pretorius, 11 Edwill van der Merwe, 10 Abner van Reenen, 9 Herschel Jantjies, 8 Evan Roos, 7 Pieter-Steph du Toit, 6 Willie Engelbrecht, 5 Marvin Orie, 4 JD Schickerling, 3 Frans Malherbe, 2 Bongi Mbonambi, 1 Steven Kitshoff (captain). Replacements (from): 16 Scarra Ntubeni, 17 Ali Vermaak, 18 Neethling Fouche, 19 Ernst van Rhyn, 20 Adre Smith, 21 Juarno Augustus, 22 Paul de Wet, 23 Tim Swiel, 24 Marcel Theunissen, 25 Dan du Plessis.
Date: Saturday 22 May
Venue: Jonsson Kings Park, Durban
Referee: Marius van der Westhuizen
Assistant Referees: Cwengile Jadezweni, Ashleigh Murray-Pretorius
Television Match Official: Stuart Berry
TV: SuperSport Rugby and Grandstand channels